Vitamin D3 replacement enhances antigen-specific immunity in older adults

Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults?

We conducted an examination of recent studies to determine whether older adults (>or=65 years) need higher levels of supplementary vitamin D than young adults when attempting to replete vitamin D status in deficient subjects, i.e. those with levels of 25-hydroxyvitamin D less than 75 nmol/L. As data on repletion with vitamin D(2) have recently been published, we restricted our discussion to the...

Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults.

BACKGROUND The relative potency of 25-hydroxyvitamin D3 to vitamin D3 needs to be better defined so that food-composition tables can better reflect the true vitamin D nutritive value of certain foods. OBJECTIVE We performed a randomized, controlled intervention study in apparently healthy, free-living adults to investigate whether the intake of 25-hydroxyvitamin D3 is 5 times more potent in r...

Efficacy of Vitamin D3 Supplementation on Physical Performance in Community-Dwelling Older Adults

Background: Impaired lower extremity muscular strength and mobility are major risk factors for falls in elderly. Vitamin D insufficiency has as well been associated with increased risk of falls and impaired physical performance. In addition, vitamin D receptors (VDR) have been identified in muscle fibers, suggesting that vitamin D has a direct effect on muscle tissue. These effects are thought ...

Lenalidomide Enhances Antigen-Specific

Safety of vitamin D3 in adults with multiple sclerosis.

BACKGROUND Vitamin D3 may have therapeutic potential in several diseases, including multiple sclerosis. High doses of vitamin D(3) may be required for therapeutic efficacy, and yet tolerability--in the present context, defined as the serum concentration of 25-hydroxyvitamin D [25(OH)D] that does not cause hypercalcemia--remains poorly characterized. OBJECTIVE The objective of the study was to...